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It is worth to mention that available reports describing the encapsulation of GSH- or albumin-protected AuNCs are limited to hydrophilic, rather than hydrophobic, matrices such as nanogels 25 , aqueous core of microcapsules 26 , silica nanoparticles, protein nanoparticles 27,28 , polymer nanoparticles 29,30 and metal-organic frameworks 31
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In a study spanning 16 weeks and including 172 male participants, the following side effects were observed following at least 16 doses (limited to one per day and a maximum of eight per month) [6]: Nausea: 12.8% Facial Flushing: 10.5% Increased Sweating: 9.3% Taste Disturbances: 4.7% These effects, particularly changes in taste, are common with peptide nasal sprays and are associated with the method of delivery